Breast Cancer Survivors Face Elevated Risk of Developing Secondary Cancers
A recent study conducted by researchers at the University of Cambridge has shed light on the increased risk of developing new cancers among breast cancer survivors. The comprehensive analysis, published in Lancet Regional Health – Europe, examined data for nearly 600,000 individuals in England and revealed the following key findings:
Increased Risk of Specific Cancers
Breast cancer survivors have double the risk of developing cancer in their other, healthy breast compared to the general population. Additionally, the risk of endometrial cancer is 87% higher, myeloid leukemia is 58% higher, and ovarian cancer is 25% higher.
Influence of Age and Genetics
Women diagnosed with breast cancer under the age of 50 have an 86% higher probability of developing a second cancer compared to the general population of the same age. For women diagnosed after 50, the risk increase is 17%. Inherited genetic mutations BRCA1 and BRCA2, known to elevate the risk of early breast cancer and ovarian cancer, may partially explain this age-related disparity.
Socioeconomic Factors
The study also uncovered a significant association between socioeconomic background and the risk of developing another cancer. Women from the most deprived backgrounds were found to be at 35% higher risk compared to those from the wealthiest backgrounds. This increased risk was particularly pronounced for lung, kidney, head and neck, bladder, esophageal, and stomach cancers, which may be attributed to higher prevalences of smoking, obesity, and alcohol consumption among more deprived groups.
Call to Action
The findings of this study underscore the importance of ongoing monitoring and support for breast cancer survivors. While further research is needed to fully understand the reasons why second primary cancers sometimes develop elsewhere in the body, it is crucial for survivors to remain vigilant about any new or unusual changes in their health. Anyone concerned about such changes should promptly contact their treatment team, GP, or a dedicated helpline for guidance and appropriate follow-up.
