Chinese scientists have engineered a deadly Ebola virus in a laboratory using a glycoprotein found in the virus that wiped out a group of hamsters within three days of the lethal injection. The researchers, from Hebei Medical University, noted that the hamsters developed “severe systemic diseases similar to those observed in human Ebola patients, including multi-organ failure,” according to the study published recently in Science Direct.
In the study, the researchers used a contagious disease of livestock and added a protein found in Ebola, which allows the virus to infect cells and spread throughout the human body. After the injection, some hamsters developed scabs over the surface of their eyeballs, affecting their vision.
Amid concerns around alleged lab leak of COVID-19 that caused the last pandemic, the Chinese researchers said that their aim was to reproduce the symptoms of Ebola in a laboratory so as to better understand the condition and prevent its spread. It is important to note that a deadly virus like Ebola needs extremely secure facilities of Biosafety Level 4 (BSL-4). Hence, the Chinese researchers used a different virus called vesicular stomatitis virus (VSV), to carry Ebola glycoprotein which plays a crucial role in helping the virus enter and infect cells of its host.
The researchers said that when they harvested the organs of the dead hamsters, they noted that the deadly virus was spread throughout their body, including the heart, spleen, lung, kidney, stomach, intestines and brain tissues, with the highest levels in the liver. Researchers further noted that the experiment provided a rapid preclinical evaluation of medical countermeasures against Ebola under BLS-2 conditions.
“Overall, this surrogate model represents a safe, effective, and economical tool for rapid preclinical evaluation of medical countermeasures against EBOV (Ebola virus) under BSL-2 conditions, which would accelerate technological advances and breakthroughs in confronting Ebola virus disease,” Science Direct quoted the researchers as saying.
