Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder that can lead to distinctive facial deformities, growth deficiencies, and developmental delays. It is often caused by a mutation in the NIPBL gene, but can also be inherited from parents. This disorder can lead to discrimination and loneliness, which is why International Cornelia de Lange Syndrome (CdLS) Awareness Day is observed every year to raise awareness and understanding of the challenges faced by those affected by CdLS.