Neurocrine Biosciences’ Phase 2 SAVITRI trial for depression therapy NBI-1065845 has reached its main goals in adults with major depressive disorder. The once-daily oral therapy indicated a statistically significant change from baseline in a clinical measure called the Montgomery-Åsberg Depression Rating Scale at Days 28 (primary) and 56 (secondary) compared to placebo. Neurocrine’s medical chief Eiry Roberts said, “The Phase 2 data are very encouraging, and we look forward to meeting with the FDA to discuss a path into Phase 3 studies.”