Nuvalent, Inc. (NUVL) presented positive data from its Phase 1/2 trials of zidesamtinib (ARROS-1) and NVL-655 (ALKOVE-1) at the European Society for Medical Oncology (ESMO) Congress 2024. The data showcased significant response rates and durable responses in heavily pretreated patients with advanced ROS1-positive and ALK-positive non-small cell lung cancer (NSCLC) and other solid tumors. Nuvalent plans to initiate a Phase 3 study for ALK-positive NSCLC in the first half of 2025.