Scientists have developed a novel gene editing approach to combat cancer drug resistance. This technique involves introducing two ‘suicide genes’ into cancer cells, making them susceptible to a specific drug and then turning them into toxin-producing machines, effectively eliminating both the modified cells and their resistant neighbors.
With climate change leading to more frequent and severe droughts, scientists are racing to develop a wheat variety that can withstand these conditions. Wheat, a staple food for billions worldwide, is particularly vulnerable to water shortages due to its high water consumption. Traditional plant breeding methods have made some progress in creating drought-tolerant varieties, but the process is slow. Gene editing techniques, which allow for more precise changes to plant DNA, are offering new hope for a truly drought-resistant wheat. While challenges remain, such as the sheer complexity of the wheat genome, scientists are making strides and believe that this agricultural Holy Grail is within reach.
Belgium has proposed excluding patented plant strains from the light-touch regulation of genetically modified crops created using modern DNA editing technology, in an effort to break a deadlock among EU governments over the issue. The proposal, which will be discussed by government delegates on May 22, addresses concerns over the patenting of novel seed varieties by agribusinesses, while also excluding herbicide-resistant strains of GMO plants from the new ‘category 1’ classification. The compromise text seeks to create a new category of GMO plant products whose genome has been modified with a limited number of tweaks using targeted mutagenesis techniques.
Profluent, a California-based AI-first protein design company, has developed an AI model capable of generating CRISPR-like proteins that do not occur naturally. These synthetic gene editors hold immense potential in developing treatments for previously incurable diseases. Profluent has also released OpenCRISPR-1, an initial open-source AI-created gene editor licensed for both research and commercial use.
Beam Therapeutics, focused on precision genetic treatments utilizing base editing, holds promise yet commands a high valuation. Partnerships with Pfizer, Apellis, Verve, and Sana have secured substantial upfront payments, bolstering its financial standing. However, the company’s lack of Phase 3 drug candidates and elevated valuation multiple raise concerns, warranting a “hold” rating for now.
Rachel Khong’s second novel, “Real Americans,” is a thought-provoking exploration of the ethical dilemmas surrounding gene editing and parental choice. Set against the backdrop of real-world scientific advancements, the story follows two families whose lives are intertwined by a twist of fate and the decisions made for their children. Khong deftly explores themes of power, identity, privilege, and the limits of human agency.
