A man’s eyelashes grew unusually long and developed a dramatic curl as a side effect of his cancer treatment with an epidermal growth factor receptor (EGFR) inhibitor. This condition, known as drug-induced trichomegaly, results from blocking EGFR, which is found in both tumor cells and healthy tissues, including hair follicles. The resulting haywire eyelash growth is a potential side effect of EGFR blockers, leading to thicker, darker, and curlier eyelashes. While usually harmless, trichomegaly can cause discomfort if the eyelashes grow towards the eyeball.